Virology
Virally-driven small interfering RNAs silence genes in pancreatic cells
Published in Obesity and Diabetes Week, November 8th, 2004
"Silencing gene expression by RNA interference (RNAi) can provide insight into gene function but requires efficient delivery of small interfering RNAs (siRNAs) into cells. Introduction of exogenous nucleic acids can be especially difficult in cultured pancreatic islets. This article describes a method for making recombinant adenoviruses that efficiently drive expression of siRNAs in islet beta-cells and a beta-cell-derived cell line," researchers in the United States report.
"Transduction with a virus expressing an siRNA specific for GLUT2 reduced GLUT2 mRNA and protein levels...
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