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Diabetic Retinopathy

Nitric oxide and cyclooxygenase-2 interact to generate diabetic eye disease

Published in Obesity and Diabetes Week, November 22nd, 2004

Nitric oxide and cyclooxygenase-2 interact to generate diabetic eye disease.

"A nonselective inhibitor of cyclooxygenase (COX; high-dose aspirin) and a relatively selective inhibitor of inducible nitric oxide synthase (iNOS; aminoguanidine) have been found to inhibit development of diabetic retinopathy in animals, raising a possibility that NOS and COX play important roles in the development of retinopathy," according to researchers in the United States.

"In this study, the effects of hyperglycemia on retinal nitric oxide (NO) production and the COX-2 pathway, and the interrelationship of the NOS and COX-2 pathways in retina and retinal cells, were...

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