HIV/AIDS-Related Insulin Resistance
Indinavir increases glucose production in healthy HIV-uninfected men
Published in Obesity and Diabetes Week, November 22nd, 2004
According to a study from the United States, "In the absence of HIV infection, changes in adipose tissue and lipid levels, HIV protease inhibitor therapy increases fasting glucose levels, suggestive of hepatic insulin resistance.
"After 4 weeks of indinavir treatment in nine HIV-negative healthy men, fasting glucose production and glycogenolysis were significantly increased. During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production."
"Therefore," J.M. Schwarz and coauthors reported, "indinavir worsens...
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