Hypertension Risk Factor

Renin-angiotensin system activated in rats with obesity and hypertension

Published in Obesity and Diabetes Week, November 22nd, 2004

The systemic and adipose renin-angiotensin system is activated in rats with diet-induced obesity and hypertension.

According to a study from the United States, "In obesity-related hypertension, activation of the renin-angiotensin system (RAS) has been reported despite marked fluid volume expansion. Adipose tissue expresses components of the RAS and is markedly expanded in obesity. This study evaluated changes in components of the adipose and systemic RAS in diet-induced obese hypertensive rats. RAS was quantified in adipose tissue and compared with primary sources for the circulating RAS. Male Sprague-Dawley rats were fed either a low-fat (LF; 11% kcal as fat) or...

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Source: Obesity and Diabetes Week (2004-11-22)

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