Insulin Resistance
Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats
Published in Obesity and Diabetes Week, November 22nd, 2004
According to a study from Kuwait, "Impaired glucose uptake and metabolism by peripheral tissues is a common feature in both type 1 and type 2 diabetes mellitus. This phenomenon was examined in the context of oxidative stress and the early events within the insulin signaling pathway using soleus muscles derived from non-obese, insulin-resistant type 2 diabetic Goto-Kakizaki (GK) rats, a well-known genetic rat model for human type 2 diabetes. Insulin-stimulated glucose transport was impaired in soleus muscle from GK rats."
"Oxidative and non-oxidative glucose disposal pathways...
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