Carboxylesterase 3 is major adipocyte lipase

"Hydrolysis of triglycerides is central to energy homeostasis in white adipose tissue (WAT). Hormone-sensitive lipase (HSL) was previously felt to mediate all lipolysis in WAT. Surprisingly, HSL-deficient mice show active HSL-independent lipolysis, suggesting that other lipases also mediate triglyceride hydrolysis. To clarify this, we used functional proteomics to detect non-HSL lipases in mouse WAT. After cell fractionation of intra-abdominal WAT, most non-HSL neutral lipase activity is localized in the 100,000 x g infranatant and fat cake fractions," investigators in Canada report.

"By oleic...

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