Diabetes Pathogenesis

Reduced glucose oxidation in type 2 diabetic subjects may have genetic origin

Published in Obesity and Diabetes Week, November 29th, 2004

The reduced insulin-mediated glucose oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin.

According to a study from Denmark, "Several defects in response to insulin have been described in vivo and in vitro in type 2 diabetes: a decreased glucose transport, defective glucose oxidation, and altered glycogen synthesis. At present, it is unknown whether glucose oxidation is primarily affected or secondarily affected by increased free fatty acids (FFA), for example. The aim of this study was to evaluate whether myotubes established from type 2 diabetic subjects express a primarily or a FFA-induced reduced insulin-mediated glucose oxidation. We...

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Source: Obesity and Diabetes Week (2004-11-29)

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