Endocrinology

DHEA increases insulin-mediated glucose disposal in hypoadrenal women

Published in Obesity and Diabetes Week, November 29th, 2004

Mayo Clinic researchers found that dehydroepiandrosterone (DHEA) significantly increased insulin-mediated glucose disposal in a group of hypoadrenal women.

The finding led them to question the need for DHEA in this patient population.

"Dehydroepiandrosterone and its sulfated ester (DHEAS) are the most abundant circulating steroid hormones. Their physiological function has yet to be determined. Hypoadrenal subjects lack this hormone because DHEA replacement is not part of the current standard of care. There are conflicting reports on the impact of DHEA replacement in hypoadrenal subjects on insulin sensitivity," said K. Dhatariya and colleagues with...

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Source: Obesity and Diabetes Week (2004-11-29)

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