Endocrinology
Regulatory T cells help new fusion constructs modulate diabetes in mouse models
Published in Obesity and Diabetes Week, November 29th, 2004
According to recent research published in the journal Gene Therapy, "previous studies have demonstrated that antigen-specific tolerance could be induced by lipopolysaccharide (LPS)-stimulated B cells retrovirally transduced with an immunoglobulin-antigen (or epitope-containing peptide) fusion construct."
"To investigate the mechanism of this gene therapy system, we now adapted this approach to immunotherapy of spontaneous diabetes in nonobese diabetic (NOD) mice, a T-cell-mediated autoimmune disease triggered, in part, by a pathogenic response to glutamate...
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