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Diabetes Genomics and Genetics
Pathogenic Delta mtDNA induced deafness but not diabetic phenotypes
December 6th, 2004
Accumulation of pathogenic Delta mtDNA induced deafness but not diabetic phenotypes in mito-mice. According to recent research published in the journal Biochemical and Biophysical Research Communications, "Mito-mice carrying various proportions of deletion mutant mtDNA (DeltamtDNA) were generated by introduction of the DeltamtDNA from cultured cells into fertilized eggs of C57BL/6.1 (136) strain mice. Great advantages of mito-mice are that they share exactly the same nuclear-genome background, and that their genetic variations are restricted to proportions of pathogenic DeltamtDNA. Since accumulation of DeltamtDNA to more than 75% induced respiration defects, the...
Source: Obesity & Diabetes Week (2004-12-06)
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