Obesity & Diabetes Week

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Diabetes Pathogenesis

Calpain-related diseases reviewed

According to recent research from Italy, "Calpains are calcium-modulated proteases which respond to Ca²⁺ signals by removing limited portions of protein substrates, thereby irreversibly modifying their functions. Members of this protease family are present in a variety of organisms ranging from mammals to plants; some of them are ubiquitously expressed, while others are tissue specific. Although calpains are apparently involved in a multitude of physiological and pathological events, their functions are still poorly understood."

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