Obesity & Diabetes Week
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Diabetes Pathogenesis
Ceramide synthesis and protein kinase C play role in insulin resistance
December 6th, 2004
Intracellular ceramide synthesis and protein kinase C zeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. According to a study from Scotland, "Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insulin resistance that may develop, in part, as a consequence of a direct inhibitory effect on early insulin signaling events. Here we report work investigating the mechanism by which palmitate (a saturated free fatty acid) inhibits insulin action in rat L6 myotubes. Palmitate suppressed the insulin-induced plasma membrane recruitment and phosphorylation of protein kinase B...
Source: Obesity & Diabetes Week (2004-12-06)
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