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Diabetes Pathogenesis
Enzyme-to-enzyme channeling in glycolysis in pancreatic islets examined
December 6th, 2004
Investigators describe enzyme-to-enzyme channeling in the early steps of glycolysis in rat pancreatic islets in a recent issue of Endocrine. According to published research from Belgium, "The enzyme-to-enzyme channeling of metabolic intermediates is not an uncommon process. The present review draws attention to recent experimental work documenting, in rat pancreatic islets, the enzyme-to-enzyme channeling of alpha-D-glucose 6-phosphate between hexokinase isoenzymes, mainly glucokinase, and phosphoglucoisomerase. Likewise, the possible enzyme-to-enzyme channeling of beta-D-fructose 6-phosphate between phosphoglucoisomerase and phosphofructokinase is briefly...
Source: Obesity & Diabetes Week (2004-12-06)
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