Obesity & Diabetes Week
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Diabetes Pathogenesis
Insulin resistance prevented by inhibition of nuclear factor kappa B
December 6th, 2004
Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. According to a study from the United States, "Recent studies have implicated inhibitor of kappaB kinase (IKK) in mediating fatty acid (FA)-induced insulin resistance. How IKK causes these effects is unknown. The present study addressed the role of nuclear factor kappaB (NFkappaB), the distal target of IKK activity, in FA-induced insulin resistance in L6 myotubes, an in vitro skeletal muscle model." "A 6-hour exposure of myotubes to the saturated FA palmitate reduced insulin-stimulated glucose uptake by...
Source: Obesity & Diabetes Week (2004-12-06)
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