Obesity & Diabetes Week

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Diabetes Pathogenesis

Src tyrosine kinase regulates insulin-induced protein kinase C delta

"Insulin stimulation of skeletal muscle results in rapid activation of protein kinase C delta (PKC-delta), which is associated with its tyrosine phosphorylation and physical association with insulin receptor (IR). The mechanisms underlying tyrosine phosphorylation of PKC-delta have not been determined. In this study, we investigated the possibility that the Src family of nonreceptor tyrosine kinases may be involved upstream insulin signaling. Studies were done on differentiated rat skeletal myotubes in primary culture," scientists in Israel report.

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