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Diabetes Research
Atomic structure of enzyme HSD-1 reported, use in diabetes treatment studied
December 6th, 2004
Syrrx Inc., a structure-based drug discovery company, reported the publication of the atomic structure of human 11(beta)-hydroxysteroid dehydrogenase type-1 (HSD-1). HSD-1 inhibitors are being investigated in clinical trials for the potential treatment of type 2 diabetes. Studies to date indicate that HSD-1 helps regulate levels of cortisol, a steroid hormone that plays an important role in controlling blood pressure and cardiovascular function as well as in regulating the body's use of proteins, carbohydrates, and fats. As such HSD-1 has been implicated in the development of obesity and type II diabetes. HSD-1 inhibitors may have potential in treating type 2 diabetes,...
Source: Obesity & Diabetes Week (2004-12-06)
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