Obesity & Diabetes Week
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Diabetic Cardiomyopathy
Regulation of aminopeptidase in cardiomyocytes examined
December 6th, 2004
Researchers have studied the regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes. According to a study from the United States, "In adipocytes and cardiac or skeletal muscle, glucose transporter isoform 4 (GLUT4) is targeted to insulin-responsive intracellular membrane vesicles (IRVs) that contain several membrane proteins, including insulin-responsive aminopeptidase (IRAP) that completely colocalizes with GLUT4 in basal and insulin-treated cells. Cardiac GLUT4 content is reduced by 65% to 85% in IRAP knockout mice, suggesting that IRAP may...
Source: Obesity & Diabetes Week (2004-12-06)
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