Obesity & Diabetes Week
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Diabetic Nephropathy
Early onset of cisplatin nephrotoxicity reported in diabetic rats
December 6th, 2004
Diabetic rats treated with insulin experienced early onset of cisplatin-induced nephrotoxicity. "Mechanism of protection against cisplatin nephrotoxicity in streptozotocin-diabetic rats is unclear but is associated with decreased renal platinum accumulation. This study was designed to determine whether normalization of hyperglycemia by insulin treatment to 6-week streptozotocin-diabetic rats reversed protection against cisplatin nephrotoxicity. Male Sprague-Dawley rats divided into three groups (n=10/group): (1) non-diabetic, (2) untreated streptozotocin-diabetic, and (3) insulin-treated streptozotocin-diabetic groups were rendered diabetic using streptozotocin (65...
Source: Obesity & Diabetes Week (2004-12-06)
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