Obesity & Diabetes Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Obesity & Diabetes Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Diabetic Nephropathy
Tranilast reduces mesenteric vascular collagen deposition in diabetes
December 6th, 2004
Tranilast reduces mesenteric vascular collagen deposition and chymase-positive mast cells in experimental diabetes. "The mast cell has a central role in the pathogenesis of fibrosis a common feature of diabetic microvascular complications. Increased mast cell numbers have been demonstrated in diabetic nephropathy in association with renal fibrosis, and diabetes acutely increases mast cell infiltration in the mesentery. Antimast cell agents such as tranilast may ameliorate the acute vascular changes in diabetes due to stabilization of mast cells and/or reduction in mast cell numbers," scientists writing in the Journal of Diabetes and Its Complications...
Source: Obesity & Diabetes Week (2004-12-06)
|
