Obesity & Diabetes Week
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Diabetic Retinopathy
Cyclooxygenase-2 inhibition lowers prostaglandin levels in diabetic rat retinas
December 6th, 2004
Cyclooxygenase-2 inhibition lowers prostaglandin levels in diabetic rat retinas. "Up-regulation of cyclooxygenase-2 occurs in retinal cells during the early onset of diabetic retinopathy. Under these conditions, prostaglandin production is elevated, which in turn leads to an increased expression of vascular endothelial growth factor (VEGF)- a growth factor implicated in vascular leakage and neovascularization," scientists in the United States report. "In this ex vivo study, we tested whether cyclooxygenase-1 or cyclooxygenase-2 is responsible for diabetes-induced secretion of prostaglandin E-2 from isolated rat retinas," said S.P. Ayalasomayajula and...
Source: Obesity & Diabetes Week (2004-12-06)
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