Obesity & Diabetes Week
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Insulin Resistance
IKK-beta inhibitor ameliorates obesity-linked insulin resistance
December 6th, 2004
A novel IKK-beta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. According to a study from Japan, "Adiponectin is an anti-diabetic and anti-atherogenic hormone that is exclusively secreted from fat cells. Serum adiponectin levels are reduced in obese patients and obese model mice, despite increased adipose tissue mass. Elucidation of the mechanisms by which plasma adiponectin levels are decreased in obese and diabetic patients would provide insight into the cause of obesity-induced diabetes and the development of therapeutic advances. In the present study, the regulation of adiponectin secretion was investigated using 3T3-L1...
Source: Obesity & Diabetes Week (2004-12-06)
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