Obesity & Diabetes Week
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Leptin Studies
Hyperleptinemia prevents lipotoxic cardiomyopathy in transgenic mice
December 6th, 2004
Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice. According to recent research from the United States, "The physiologic function of the progressive hyperleptinemia of diet-induced obesity is unknown. However, that lipotoxicity in nonadipose tissues of congenitally unleptinized obese rodents is far greater than in hyperleptinemic diet-induced obesity rodents has suggested an antilipotoxic role. To test this hypothesis, mice with severe lipotoxic cardiomyopathy, induced transgenically by cardiomyocyte-specific overexpression of the acyl CoA synthase (ACS) gene, were made hyperleptinemic by treatment with recombinant adenovirus...
Source: Obesity & Diabetes Week (2004-12-06)
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