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Angiology
High glucose levels impair nitric oxide-related VEGF synthesis
December 6th, 2004
High glucose levels impair nitric oxide-related VEGF synthesis. According to recent research published in the journal Life Sciences, "synthesis of vascular endothelial growth factor (VEGF), the major angiogenic molecule, is induced by nitric oxide (NO) in various cell types, including vascular smooth muscle cells (VSMC). Therefore, compounds which inhibit NO generation can also influence VEGF synthesis." "Here we investigated the effect of increased glucose concentration (25 mM vs. 5.5 mM) on cytokine-induced VEGF synthesis in rat VSMC. The cells growing in the medium containing 5.5 mM glucose and exposed to interleukin (IL)-1-beta, tumor...
Source: Obesity & Diabetes Week (2004-12-06)
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