Autoimmune Diabetes

Diabetes is prevented when costimulatory molecules are down-regulated in mice

Published in Obesity and Diabetes Week, December 6th, 2004

Diabetes is prevented when costimulatory molecules are down-regulated in mice.

"Phenotypically 'immature' dendritic cells (DCs), defined by low cell surface CD40, CD80, and CD86 can elicit host immune suppression in allotransplantation and autoimmunity. Herein, we report the most direct means of achieving phenotypic immaturity in non-obese diabetes (NOD) bone marrow-derived DCs aiming at preventing diabetes in syngeneic recipients," scientists in the United States report.

"CD40, CD80, and CD86 cell surface molecules were specifically down-regulated by treating NOD DCs ex vivo with a mixture of antisense oligonucleotides targeting the CD40, CD80, and...

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Source: Obesity and Diabetes Week (2004-12-06)

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