Published in Obesity and Diabetes Week, December 20th, 2004
According to published research from Belgium, "In catabolic conditions, atrogin-1/MAFbx, a muscle-specific ubiquitin-ligase required for muscle atrophy, is increased, and concentrations of IGF-I, a growth factor known to have antiproteolytic action, are reduced. To define the relationship between the decline in IGF-I and the induction of atrogin-1/MAFbx, we studied the effect of IGF-I replacement on atrogin1/MAFbx mRNA in rats fasted for 51 hours and in rats made diabetic with streptozotocin (STZ). Fasting produced a...
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