Diabetes Pathogenesis

IGF-I decline in induction of atrogin-1/MAFbx in diabetes studied

Published in Obesity and Diabetes Week, December 20th, 2004

Scientists have investigated the role of the insulin-like growth factor I (IGF-I) decline in the induction of atrogin-1/MAFbx during fasting and diabetes.

According to published research from Belgium, "In catabolic conditions, atrogin-1/MAFbx, a muscle-specific ubiquitin-ligase required for muscle atrophy, is increased, and concentrations of IGF-I, a growth factor known to have antiproteolytic action, are reduced. To define the relationship between the decline in IGF-I and the induction of atrogin-1/MAFbx, we studied the effect of IGF-I replacement on atrogin1/MAFbx mRNA in rats fasted for 51 hours and in rats made diabetic with streptozotocin (STZ). Fasting produced a...

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Source: Obesity and Diabetes Week (2004-12-20)

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