Diabetes Pathogenesis
Calcium and glycolysis mediate multiple bursting modes in pancreatic islets
Published in Obesity and Diabetes Week, January 3rd, 2005
"Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to stimulatory glucose levels. These bursts often have a regular repeating pattern, with a period of 10-60 seconds. In some cases, however, the bursts are episodic, clustered into bursts of bursts, which we call compound bursting. Consistent with this are recordings of free Ca2+ concentration, oxygen consumption, mitochondrial membrane potential, and intra-islet glucose levels that exhibit very slow oscillations, with faster oscillations superimposed," scientists writing in the Biophysical...
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