Published in Obesity and Diabetes Week, January 3rd, 2005
"Inhibition of protein tyrosinephosphatase 1B (PTP1B)has been proposed as a novel therapy to treat type 2 diabetes and obesity. In order to identify novel PTP1B inhibitors, we have developed a robust screen in Saccharomyces cerevisiae where growth is dependent on PTP1B catalytic activity. This was based on the observation that overexpression of v-Src, a tyrosine kinase, in yeast leads to lethality through mitotic dysfunction and this lethality can be reversed by co-expression of PTP1B," scientists in Canada report.
"The expression levels of v-Src and PTP1B...
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