Drug Development
Yeast used to screen for inhibitors of protein tyrosine phosphatase 1B
Published in Obesity and Diabetes Week, January 3rd, 2005
"Inhibition of protein tyrosinephosphatase 1B (PTP1B)has been proposed as a novel therapy to treat type 2 diabetes and obesity. In order to identify novel PTP1B inhibitors, we have developed a robust screen in Saccharomyces cerevisiae where growth is dependent on PTP1B catalytic activity. This was based on the observation that overexpression of v-Src, a tyrosine kinase, in yeast leads to lethality through mitotic dysfunction and this lethality can be reversed by co-expression of PTP1B," scientists in Canada report.
"The expression levels of v-Src and PTP1B...
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