Obesity and Diabetes
Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1
Published in Obesity and Diabetes Week, January 3rd, 2005
"Obesity and stress inhibit insulin action by activating protein kinases that enhance serine phosphorylation of IRS1 and have been thus associated to insulin resistance and the development of type 2 diabetes. The protein kinase C theta (PKC-theta) is activated by free-fatty acids, and its activity is higher in muscle from obese diabetic patients. However, a molecular link between PKC-theta and insulin resistance has not been defined yet," investigators in the United States report.
"Here we show that PKC-theta phosphorylates IRS1 at serine 1101 blocking...
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