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ACE Inhibitors

Coronary flow response to bradykinin is preserved by ACE inhibitors in aged mice

Published in Obesity and Diabetes Week, January 17th, 2005

A recent report describes endothelial nitric oxide synthase-independent effects of an ACE inhibitor on coronary flow response to bradykinin in aged mice.

According to recent research from Japan, "ACE inhibitors are known to ameliorate cardiovascular complications in aging; however, their effects on the coronary circulation in relation to aging and eNOS dependence remain to be examined."

M.A. Talukder and colleagues of Kyushu University explained, "Coronary flow responses to bradykinin with or without ACE inhibitors were examined in Langendorff-perfused hearts from young (16-20 weeks) and aged (16-20 months) control and eNOS-/- mice....

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