Proteomics
Postnatal exposure to leptin causes altered adult female phenotype
Published in Obesity and Diabetes Week, January 17th, 2005
According to recent research from the United States, "We investigated the effect of daily intracerebroventricular (ICV) leptin administration (neonatal age 2 to 7 days) on hypothalamic neuropeptides (neuropeptide Y, alpha-melanocyte-stimulating hormone) that regulate food intake, body weight (BW) gain, and the metabolic/hormonal profile in suckling (8 and 21 days) and adult rat (35, 60, 90, and 120 days). ICV leptin (0.16 mcg/g BW/dose; n=70) led to a postnatal decline in BW (p=0.0002) that persisted only in the adult females (p=0.002)."
"The postnatal...
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