Obesity and Diabetes
Free fatty acid levels modulate microvascular function
Published in Obesity and Diabetes Week, January 24th, 2005
"To test the hypothesis that free fatty acids (FFAs) modulate microvascular function and that this contributes to obesity-associated insulin resistance, hypertension, and microangiopathy, we examined the effects of both FFA elevation in lean women and FFA lowering in obese women on skin microvascular function. A total of 16 lean and 12 obese women underwent, respectively, intralipid plus heparin (or saline) infusion and overnight acipimox (or placebo) treatment. We measured capillary recruitment with capillaroscopy and endothelium-independent vasodilation by iontophoresis of acetylcholine and sodium nitroprusside...
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