Diabetes Pathogenesis
Recent findings in diabetes pathogenesis provide new insights
Published in Obesity and Diabetes Week, January 31st, 2005
Study 1: Ca2+-induced Ca2+ release via inositol 1,4,5-trisphosphate receptors is amplified by protein kinase A and triggers exocytosis in pancreatic beta cells.
According to recent research from Sweden, "Hormones, such as glucagon and glucagon-like peptide-1, potently amplify nutrient stimulated insulin secretion by raising cAMP. We have studied how cAMP affects Ca2+-induced Ca2+ release (CICR) in pancreatic beta cells from mice and rats and the role of CICR in secretion. CICR was observed as pronounced Ca2+...
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