Diabetes Pathogenesis
Reports advance knowledge in diabetes pathogenesis research
Published in Obesity and Diabetes Week, January 31st, 2005
Study 1: Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
"The insulin and IGF signaling pathways are critical for development and maintenance of pancreatic beta-cell mass and function. The serine-threonine kinase Akt is one of several mediators regulated by these pathways. We have studied the role of Akt in pancreatic beta-cell physiology by generating transgenic mice expressing a kinase-dead mutant of this enzyme in beta cells. Reduction of Akt activity in...
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