Published in Obesity and Diabetes Week, January 31st, 2005
"The insulin and IGF signaling pathways are critical for development and maintenance of pancreatic beta-cell mass and function. The serine-threonine kinase Akt is one of several mediators regulated by these pathways. We have studied the role of Akt in pancreatic beta-cell physiology by generating transgenic mice expressing a kinase-dead mutant of this enzyme in beta cells. Reduction of Akt activity in...
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