Diabetes Pathogenesis
Studies describe new findings in diabetes pathogenesis research
Published in Obesity and Diabetes Week, February 7th, 2005
Study 1: Ascorbic acid recycling is impaired by increased glucose metabolism in cultured beta cells.
"Ascorbic acid is necessary for optimal insulin secretion from pancreatic islets. We evaluated ascorbate recycling and whether it is impaired by increased glucose metabolism in the rat beta-cell line INS-1. INS-1 cells, engineered with the potential for overexpression of glucokinase under the control of a tetracycline-inducible gene expression system, took up and reduced dehydroascorbic acid to ascorbate in a concentration-dependent manner that was optimal in the...
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