Diabetic Cardiomyopathy
Antioxidants attenuate hyperglycemia-induced cardiomyocyte death
Published in Obesity and Diabetes Week, February 14th, 2005
According to recent research from Italy, "Diabetes and oxidative stress concur to cardiac myocyte death in various experimental settings. We assessed whether N-acetyl-L-cysteine (NAC), an antioxidant and glutathione precursor, has a protective role in a rat model of streptozotocin (STZ)-induced diabetes and in isolated myocytes exposed to high glucose (HG). Diabetic rats were treated with NAC (0.5 g/kg per day) or vehicle for 3 months. At sacrifice, left ventricle (LV) myocyte number and size, collagen deposition, and reactive oxygen species (ROS) were measured by quantitative...
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