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Metabolic Syndrome

Weight loss reduces circulating ADMA concentrations in morbidly obese women

Published in Obesity and Diabetes Week, February 14th, 2005

Weight loss reduces circulating asymmetrical dimethyl-L-arginine concentrations in morbidly obese women, researchers report.

K. Krzyzanowska and colleagues, University Hospital Rudolf Virchow, Vienna, Austria, wrote, "The endogenous nitric oxide-synthase inhibitor asymmetrical dimethyl-L-arginine (ADMA) is elevated in patients with increased risk for arteriosclerosis. Obesity is a risk factor for cardiovascular disease. We measured plasma ADMA concentrations in morbidly obese women before and after weight loss following gastroplastic surgery.

"ADMA and symmetrical dimethyl-L-arginine concentrations were analyzed by HPLC from 34 female patients (age...

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