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Diabetic Nephropathy

Researchers describe findings in diabetic nephropathy studies

Published in Obesity and Diabetes Week, February 21st, 2005

Diabetic nephropathy research advances have been reported from the United Kingdom, United States and Republic of Korea.

Study 1: Inhibition of transglutaminase activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cells.

According to a study from England, "Diabetic nephropathy affects 30-40% of diabetics leading to end-stage kidney failure through progressive scarring and fibrosis. Previous evidence suggests that tissue transglutaminase (tTg) and its protein cross-link product epsilon(gamma-glutamyl) lysine contribute to the expanding renal tubulointerstitial and glomerular basement membranes...

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