Published in Obesity and Diabetes Week, February 21st, 2005
"Previous studies demonstrated that an adipose tissue-specific element (ASE) of the murine GLUT4 gene is located between -551 and -506 in the 5'-flanking sequence and that a high-fat responsive element for down-regulation of the GLUT4 gene is located between bases -701 and -552. A binding site for nuclear factor 1 (NF1), which mediates insulin and cAMP-induced repression of GLUT4 in 3T3-L1 adipocytes, is located between bases -700 and -688. To examine the role of NF1 in the regulation of GLUT4 gene expression in white adipose tissues (WAT) in vivo, we created two types of transgenic...
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