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Diabetes Therapy

Hepatic insulin gene therapy may treat type 1 diabetes

Published in Obesity and Diabetes Week, February 28th, 2005

Hepatic insulin gene therapy may treat type 1 diabetes.

According to recent research published in the journal Diabetes Research and Clinical Practice, "the development of type I diabetes results from the almost total destruction of insulin-producing pancreatic cells by autoimmune responses specific to cells. Standard insulin therapy may not maintain blood glucose concentrations within the relatively narrow range that occurs in the presence of normal pancreatic cells."

"We used a recombinant adeno-associated virus (rAAV) that expresses a single-chain insulin analogue (SIA), which possesses biologically active insulin activity without enzymatic...

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