Insulin Resistance

Pro12Ala polymorphism of PPAR-gamma gene linked to insulin resistance

Published in Obesity and Diabetes Week, March 7th, 2005

The Pro12Ala polymorphism of the PPAR-gamma gene is associated with insulin resistance.

"To clarify the contribution of the Pro12A1a polymorphism of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene to susceptibility to insulin resistance and related diseases, 505 unrelated Japanese subjects were investigated, including 175 normotensive non-diabetic (NN) subjects, 125 normotensive diabetic (ND) subjects, 102 hypertensive non-diabetic (HN) subjects, and 103 hypertensive diabetic (HD) subjects. Ala phenotype frequency was lowest in patients with both type 2 diabetes and hypertension (3.9% in HD group), followed by patients with either one of these...

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Source: Obesity and Diabetes Week (2005-03-07)

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