Metabolic Syndrome

Scientists show knocking out two key signals will cause diabetes

Published in Obesity and Diabetes Week, March 7th, 2005

Using a revolutionary technique to turn off chemical signals inside the cell, scientists at Joslin Diabetes Center have discovered that the different metabolic abnormalities present in type 2 diabetes can be caused by knocking out two key signals in liver cells.

Their findings in mice may someday lead to strategies in humans to boost these two different signals, providing a powerful new way to treat the different metabolic components present in the most common form of diabetes.

"By lowering the level of two key insulin signaling proteins in liver cells, we began to uncover just how complex type 2 diabetes and the related metabolic syndrome are," said...

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Source: Obesity and Diabetes Week (2005-03-07)

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