Diabetes Pathogenesis
High glucose upregulates nitric oxide synthase gene expression
Published in Obesity and Diabetes Week, March 14th, 2005
"Diabetes is associated with oxidative stress and increased concentrations of inflammatory cytokines. The aim of the study was to assess the effects of inflammatory cytokines and oxidative stress associated with increased glucose concentrations on inducible nitric oxide synthase (iNOS) promoter activity in intestinal epithelial cells. High glucose (25 mmol/L) conditions reduced glutathione (GSH) concentrations in the human intestinal epithelial cell line, DLD-1," researchers in the United Kingdom...
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