Published in Obesity and Diabetes Week, March 14th, 2005
According to recent research from Japan, "We have investigated the protective effect of YM598, a selective endothelin type A receptor antagonist, against an endothelia-l-induced proliferation of rat mesangial cells and renal function in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. YM598, but not K-8794, a selective endothelin type B receptor antagonist, inhibited the endothelia-1-induced proliferation of cultured mesangial cells derived from intact Wistar rats in a concentration-dependent manner. YM598 (0.1 or 1 mg/kg), enalapril (5...
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