Atherosclerosis

Amyloid A3 expression stimulated by dexamethasone and IL-6

Published in Obesity and Diabetes Week, March 14th, 2005

Serum amyloid A3 expression is stimulated by dexamethasone and interleukin-6 in 3T3-L1 adipocytes.

According to recent research published in the Journal of Endocrinology, "A chronic increase in systemic levels of acute-phase reactants contributes to the development of insulin resistance and associated disorders such as cardiovascular disease. Recently, serum amyloid A3 (SAA3) has been characterized as an adipocyte-secreted acute-phase reactant, expression of which is dramatically increased in insulin resistance and obesity. To further clarify expression and regulation of this adipocytokine in fat, SAA3 mRNA was measured by quantitative real-time reverse...

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Source: Obesity and Diabetes Week (2005-03-14)

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