Insulin Resistance

Acid-base balance influence risk for insulin resistance syndrome

Published in Obesity and Diabetes Week, March 28th, 2005

Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output.

According to a study from the United States, "Frank metabolic acidosis is known to promote renal excretion of hydrogen ion by induction of glutaminase and other enzymes in the renal tubules. This induction, at least in part, reflects an increase in pituitary output of ACTH and a consequent increased production of cortisol and aldosterone; these latter hormones act on the renal tubules to promote generation of ammonia, which expedites renal acid excretion. Recent evidence suggests that the moderate metabolic acidosis associated with a protein-rich diet low in organic...

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Source: Obesity and Diabetes Week (2005-03-28)

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