Diabetes Pathogenesis
Type 2 diabetes - A matter of beta-cell life and death?
Published in Obesity and Diabetes Week, March 28th, 2005
"In type 2 diabetes, the beta cells of the pancreas fail to produce enough insulin to meet the body's demand, in part because of an acquired decrease in beta-cell mass. In adults, pancreatic beta-cell mass is controlled by several mechanisms, including beta-cell replication, neogenesis, hypertrophy, and survival. Here, I discuss evidence supporting the notion that increased beta-cell apoptosis is an important factor contributing to beta-cell loss and the onset of type 2 diabetes," a scientist in the United States reports.
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