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Obesity and Diabetes

Insulin delivery to muscles delayed after oral glucose load in obese subjects

Published in Obesity and Diabetes Week, March 28th, 2005

Transcapillary delivery of insulin to muscle interstitial fluid is delayed after an oral glucose load in obese subjects.

According to a study from Sweden, "Obese subjects exhibit a delay in insulin action and delivery of insulin to muscle interstitial fluid during glucose/insulin infusion. The aim of the present study was to follow the distribution of insulin to skeletal muscle after an oral glucose load in obese subjects. We conducted an oral glucose tolerance test (OGTT) in 10 lean and 10 obese subjects (BMI 23±0.6 vs 33±1.2 kg/m2; p<0.001). Insulin measurements in muscle interstitial fluid were combined with forearm arteriovenous...

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