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Obesity and Diabetes

NADPH oxidase plays role in oxidative stress in adipocytes

Published in Obesity and Diabetes Week, April 4th, 2005

NADPH oxidase plays a role in PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice.

According to a study from Israel, "Oxidative stress is thought to be one of the causative factors contributing to insulin resistance and type 2 diabetes. Previously, we showed that reactive oxygen species (ROS) production is significantly increased in adipocytes from high-fat diet-induced obese and insulin-resistant mice (HF). ROS production was also associated with the increased activity of PKC-delta."

"In the present studies, we hypothesized that PKC-delta contributes to ROS generation and determined their...

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