Hypertension Risk Factors
Renal angiotensin receptors mediate natriuresis/diuresis in obese rats
Published in Obesity and Diabetes Week, April 4th, 2005
"Recently, there has been a growing interest in studying the role of angiotensin II type-2 (AT2 ) receptor in renal/cardiovascular function in pathological conditions. The present study was designed to determine the functional role of the AT2 receptors on natriuresis/diuresis and compare the level of the tubular AT2 receptor expression in obese and lean Zucker rats (12 weeks old). Under anesthesia, candesartan (angiotensin II type 1 [AT1] ] ]-specific antagonist; 100 mcg/kg bolus) produced...
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