Type 2 Diabetes
Insulin gene variable number tandem repeat is a genetic risk factor
Published in Obesity and Diabetes Week, April 11th, 2005
According to J.B. Meigs and colleagues, Massachusetts General Hospital, "Abnormalities in insulin regulation are central to the pathogenesis of type 2 diabetes. We assessed variation in the insulin gene variable number tandem repeat (INS VNTR) minisatellite (using the -23Hph1 A/T single nucleotide polymorphism) as a risk factor for 92 cases of incident type 2 diabetes in 883 unrelated Framingham Heart Study (FHS) subjects and in a separate sample of 698 members of 282 FHS nuclear families with 62 diabetes cases."
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